A hidden immune pathway may help explain why Alzheimer’s inflammation persists
A newly identified epigenetic pathway reveals how overactive microglia may sustain brain inflammation in Alzheimer’s, suggesting KAT7 as a potential target for future therapies.
Study: Epigenetic control of microglial mitochondrial immunity by KAT7 drives Alzheimer’s disease pathogenesis. Image Credit: ART-ur / Shutterstock
A recent study published in the journal Neuron suggests that KAT7, a histone acetyltransferase protein, may contribute to brain inflammation in Alzheimer’s disease (AD) through altered microglial immune signaling.
The brain contains immune cells called microglia. These cells keep the brain healthy in normal conditions. KAT7 promotes pro-inflammatory microglial activation via mitochondrial immune signaling, thereby triggering brain inflammation.
Read the Full Research
For the full scientific details, study methodology, and complete article, please visit the original publisher.
Read Full Article on Publisher Website →